Seminar: Itziar Martinez Gonzalez

Immunological memory of ILC2s

Group 2 Innate Lymphoid Cells (ILC2s) are abundant in barrier tissues, where they sense tissue damage and orchestrate type 2 immune responses to restore homeostasis, particularly during parasite infections. When dysregulated, however, ILC2s contribute to allergic diseases like eczema and asthma. We have previously shown that mouse and human ILC2s acquire antigen-independent immunological memory. Memory ILC2s mount enhanced responses upon recall, which drive exacerbated allergic inflammation. Currently, we are investigating memory ILC2 mediated cross-tissue inflammation. Understanding the role of memory ILC2s in our organism may provide novel insights into how the immune system links seemingly unrelated diseases.