Seminar: Sarah Crome

Balancing act: Innate lymphoid cells as rheostats of adaptive immunity

Professor Crome’s research explores immune tolerance, immunotherapy, and the role of innate lymphoid cells (ILCs) in human health and disease. Her team combines patient-based studies with single-cell and spatial technologies, advanced immunological platforms, and humanized models, to dissect mechanisms of ILC development and function as part of protective or pathogenic cellular circuits in transplantation, autoimmunity and cancer. These efforts have uncovered pivotal roles for ILCs in tuning adaptive immune responses and maintaining immune homeostasis. Translational work in her lab focuses on designing novel strategies to target or harness ILC2s and Natural Killer (NK) cells in immunotherapies and immune-engineering approaches.