Faculty of Science
Microbiology and Immunology

A secreted Tapasin isoform impairs cytotoxic T lymphocyte recognition by disrupting exogenous MHC class I antigen presentation

gene schematic

Publication Date

Publication Journal

Frontiers in Immunology

Author(s)

Robyn P. Seipp, Guillaume Hoeffel, Alexander R. Moise, Siri Lok, Anne-Claire Ripoche, Concepcion Maraño, Anne Hosmalin, and Wilfred A. Jefferies

This study investigates how cells use Tapasin proteins to present markers on their surface, allowing immune cells to recognize and target infection or disease. The authors found that two forms of Tapasin help cells to present these markers, while one form of Tapasin inhibits this process. The researchers propose that a balance between these two activities provides fine control over the immune system, enabling it to combat pathogenic cells without damaging healthy tissue.

  • Jefferies Lab

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Microbiology and Immunology

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