Jim Sun
Jim Sun
Assistant Professor
Research Faculty
Office Tel
Office Location
2506 - 2350 Health Sciences Mall, Life Sciences Centre
Lab Name
Sun Lab
Lab Tel
Lab Location
2540 - 2350 Health Sciences Mall, Life Sciences Centre
Associated Departments
Department of Microbiology and Immunology
Research Group
Host-directed Therapy
Infection, Immunity, and Inflammation
Macrophage Biology
Research Interests

The Sun laboratory is focused on understanding host immunity to Mycobacterium tuberculosis (Mtb) and other bacterial infectionsInfection with Mtb causes tuberculosis (TB), which remains the leading cause of infectious diseases related deaths worldwide due to a single bacterial pathogen. Multi-drug resistant TB (MDR-TB) is also the single largest disease component of the global antimicrobial resistance crisis, a pandemic lurking in the shadows that is predicted to cause 10 million death per year by 2050.

Our goal is to develop novel host-directed therapies for TB and other bacterial infections. Targeting and harnessing the power of our own immune cells to kill invading pathogens offers unique promise to overcome the development of antibiotic resistance.

My research program has two major pillars:

  • Knowledge generation: identify and functionally characterize novel host and/or bacterial targets suitable for drug development using a multidisciplinary approach
  • Drug discovery: promising host and/or bacterial targets are then put through a preclinical drug development pipeline with the goal of clinical translation

Our long-term vision is to apply our discoveries not only to address TB, but also to combat emerging pathogens and antimicrobial resistance.

For more information about specific research projects, please visit https://www.thesunlab.ca/research/projects